The new cell biology
I have not been a very faithful blogger the last few months – whether that will change in the new year remains to be seen. I travelled more in November than usual and then spent December getting caught up on some book reviews, referees reports etc. that I had been asked for and had agreed to do. Among other things, I have been left with a pile of reading to catch up on. One thing that caught my attention as I began to do so was three related front-of-the-magazine pieces in Nature on December 1st, the first of which here was called “the new cell anatomy”.
Apparently a mixture of biophysicists, cell biologists and biochemists in recent years have been discovering all kinds of previously unknown structures inside of cells. The phenomena and terminology are bewilderingly diverse – various “tubes, sacs, clumps, strands and capsules” including filaments, nanotubes, purinosomes, microcompartments, carboxysomes, exosomes, cytoophidia (cell serpents) – some of which concepts undoubtedly will last, others of which undoubtedly will not. A lot of the discussion has been about the development of new methods as well as of applying old methods to single cells accompanied by a fair amount of arm waving about possible medical and industrial applications.
My point is that I hope in all of this, at least some of the researchers will keep their eye on a different question. As the late Lynn Margulis among others showed – there is a lot of knowledge to be gained about evolution working between the cell and the molecule, including by microscopy, newer fancier versions of which play a role in some of the new work. Since nobody thinks that life began de novo with prokaryotic cells fully formed, and since evolution always, always leaves marks of its history, there surely is a lot to be learned about the origin and early evolution of life by peering into, prodding and manipulating existing cells. So I very much look forward to eventually hearing more about the implications of the new work for that subject.